miRNAs (expression) | Effects on cancer cells and mechanism of action | Potential targeting therapy | Refs. |
---|---|---|---|
miR-500a-5p | CAFs promotes breast cancer progression and metastasis through exosome miR-500a-5p | By binding to ubiquitin-specific peptidase 28 | [76] |
miR-92 | miR-92 secreted by CAFs significantly promotes tumor progression and impairs the function of tumor-infiltrating immune cells in vivo | LATS2 is thought to be a target gene for miR-92, and LATS2 interacts with YAP1 | [79] |
miR-185-5p,miR-652-5p,miR-1246 | The synergistic effects of miR-185-5p, miR-652-5p, and miR-1246 promote fibroblast migration and contraction | Activate NFs to CAFs | [30] |
miR-425-5p | R-425-5p promotes conversion to the CAFs phenotype and increases cell motility | By inhibiting its target gene TGFβRII | [80] |
miR-222 | MiR-222 overexpression or LBR knockdown is sufficient to induce NFs to exhibit CAFs signatures that enhance migration, invasion, and aging | Works by targeting LBR | [81] |
miR-21, miR-143, miR-378 | miRNAs exhibit significantly increased ability to form mammary globules, increased stem cells and EMT markers, and promote cell growth | Cell phenotypic changes | [82] |
miR-146a | The miR-146a/TXNIP axis activates CAFs and activates the Wnt pathway, thereby promoting the invasion and metastasis of BC cells | Through the miR-146a/TXNIP axis, the wnt path is activated | [75] |
miR-16, miR-148a | FAK ablation in CAFs increases the level of exosome miR-148a, thereby reducing the expression of WNT1 and WNT10B in recipient cancer cells | FAK signal transduction pathway | [83] |
miR-330-5p | SNHG3 knockdown in CAF-secreted exosomes inhibits glycolytic metabolism by increasing miR-330-5p and decreasing PKM expression in tumor cells | Targeting lncRNA SNHG3 | [84] |
miR-1-3p | The elevation of miR-1-3p in breast cancer cells inhibits cell viability, invasion, migration and transformation from epithelium to mesenchymal, and inhibits tumor formation and metastasis | Targeting Gli-similar1 (GLIS1) | [85] |