Fig. 1

Discovery of the Notch 5-TSPs signature. A Selection frequency of the top 20 gene pairs. Regularized random forest was run 100 times on bootstrapped training data to select the most informative features from the list of 114 Notch-based TSPs returned by the k-TSPs algorithm. The 5 most frequently selected pairs were used in the final classifier (5-TSPs). B Boxplots showing the relative expression of each pair in resistant (RD) versus sensitive (pCR) samples. C Receiver operating characteristic (ROC) (top) and precision-recall (PRC) (bottom) curves showing the performance of the Notch 5-TSPs signature in predicting the response to NACT in the training data