Table 1 Steroids for ratios to assess the functional impact of the inversion. Conjugates were included for all steroids except progesterone and 17α-hydroxyprogesterone, which do not undergo significant conjugation
Abbreviation | Steroid | Significance |
|---|---|---|
Allo | Allopregnanolone | Inhibitory neurosteroid |
Preg | Pregnanolone | Inhibitory neurosteroid |
Iso | Isopregnanolone | Counter-inhibitory neurosteroid |
P | Progesterone | Precursor of 20α-reductase (AKR1C1) |
17-OHP | 17α-Hydroxyprogesterone | Precursor of 20α-reductase (AKR1C1) |
20α-DHP | 20α-Dihydroprogesterone | 20α-reduced metabolite of P |
17,20α-diOHP | 17α,20α-Dihydroxy-4-pregnen-3-one | 20α-reduced metabolite of 17-OHP |
DHT | 5α-Dihydrotestosterone | Precursor of 3α-reductase (AKR1C2) |
Adiol | 3α-Androstanediol | 3α-reduced metabolite of DHT |