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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Long read sequencing characterises a novel structural variant, revealing underactive AKR1C1 with overactive AKR1C2 as a possible cause of severe chronic fatigue

Fig. 5

Ratios of steroids indicating: a neurosteroid homeostasis; b 3α activity of AKR1C2; c, d 20α activity of AKR1C1; e 5α vs 5β reduction of progesterone. Allo: Allopregnanolone; Preg: Pregnanolone; Iso: Isopregnanolone; DHT: 5α-Dihydrotestosterone; Adiol: 3α-Androstanediol; 17-OHP: 17α-Hydroxyprogesterone; 17,20α-diOHP: 17α,20α-Dihydroxy-4-pregnen-3-one; P: Progesterone; 20α-DHP: 20α-Dihydroprogesterone; 5α/5β P: Sum of all 5α- vs 5β-reduced metabolites of progesterone

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Journal of Translational Medicine

ISSN: 1479-5876

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