Fig. 4

Prediction of BOR of PD with submitted models. A Bootstrapped estimates of model performance in CheckMate 026 (boxes are bound by the 25th and 75th percentiles). B Principle of the cSysImmunoOnco model. C cSysImmunoOnco model performance in CheckMate 026 and D CheckMate 227. The grey dotted line is the line of non-determination. AUC area under the curve, BL baseline, BOR best overall response, DSS BM difference in squared scaled basal metrics, EaSIeR estimate systems immune response, ICI immune checkpoint inhibitor, ICR immunologic constant of rejection, MSI microsatellite instability, NSCLC non-small cell lung cancer, OS overall survival, PD progressive disease, PD-L1 programmed death ligand 1, TMB tumor mutational burden