Fig. 1

LIPH was significantly upregulated in PDAC and was related to later pathological stage and poor prognosis. A Identification of LIPH as a potential oncogene in pancreatic cancer. B LIPH expression in PDAC was the highest among 28 cancer types. C Kaplan–Meier analysis of overall survival rate related to the expression of LIPH in 177 cases based on the TCGA database (Cutoff: Best Cutoff, High = 59, Low = 118). D Kaplan–Meier analysis of overall survival rate related to the expression of LIPH in 107 cases based on the RNA sequencing results of Ruijin patients (Cutoff: median, High = 53, Low = 54). E IF staining of LIPH in PANC-1 and CFPAC-1. F Standard IHC staining and respective sample count of LIPH expression in 99 pancreatic ductal adenocarcinoma and paired adjacent normal tissues. G The heatmap showed that staining count highly correlated with AJCC stage based on TMA. H Kaplan–Meier analysis of overall survival rate based on the IHC count (Cutoff: High (+++/++) = 85, Low (±) = 14). I Standard IHC staining in different stages of PDAC progression in KPC mice. J Univariate Cox regression analysis based on the Ruijin cohort. Scale bar = 100 µm. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001