Fig. 6

Regulation of breast cancer cell stemness by LDLR. A Hazard ratio for 9 immune stemness genes in survival models. B Expression of LDLR in a variety of tumor tissues in CPTAC. C Protein expression of LDLR in breast cancer in HPA. D Construction of MDA-MB-231 cell lines with high and low expression of LDLR. E Sphere formation experiment in MDA-MB-231 cell lines with high and low expression of LDLR. F Clonogenic Cell Survival Assay MDA-MB-231 cell lines with high and low expression of LDLR. G Four clusters of cells were obtained by flow cytometry sorting: P2–P5. H Proportion of 4 clusters of cells obtained by flow cytometry. I The sphereroids diameter and sphereroids per 500 cells in P3–P5. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001