Fig. 6
From: Peripheral signaling pathways contributing to non-histaminergic itch in humans
Modulation of non-histaminergic itch sensations by the inflammatory mediator prostaglandin E2 (PGE2). Preinjection of PGE2 was used to asses the effect of PGE2 on perception of Beta-Alanine (panels A), BAM 8-22 (panels B) and Cowhage (panels C) induced itch and pain. The first two columns show the itch (black triangles) and pain (gray diamonds) ratings (values are means ± SEM) for 420 s after the injection of the pruritogen with the pre-injection of a control solution (left column) or PGE2 (middle column). The third column shows single AUC values for itch and pain ratings provided by single volunteers. Lines connect values form the same volunteer. Significant differences are indicated (*P < 0.05)