Fig. 2
From: Peripheral signaling pathways contributing to non-histaminergic itch in humans
The application route of pruritogens causes different itch/pain rating ratios in human volunteers. The pruritogens were A β-alanine, B BAM 8-22, C cowhage extract and D chloroquine and E SIF as a control. Itch (black triangles) and pain (gray diamonds) ratings on a NRS from 0 to 10 are depicted for injection (left column) and focal application (right column) during a time series (first and second column) as mean ± SEM and the AUC (third column) for single volunteers. Significant differences are indicated (*P < 0.05)