The characteristics and the multiple functions of integrin β1 in human cancers

Table 2 The expression and functions of integrin β1 in various cancer types

Tumor type	Expression	Ligand/receptor	Receptor type	Function	Reference
Pancreatic cancer	up	Muc5ac – CD44/ integrin β1	N/A	Promote cancer progression and chemoresistance	[24]
Acute myeloid leukaemia	up	Fibronectin – integrin β1	N/A	Confer radiation and chemoresistance	[25]
Hepatocellular cancer	up	Integrin β1	N/A	Accelerate tumor growth	[26]
Ovarian cancer	up	VCAM-1 – integrin α4β1	Leukocyte-specific receptors	Cause chemotherapy resistance and metastasis	[27]
Breast cancer	up	Collagen I – integrin β1	Collagen-binding receptors	Drive invasion, metastasis, angiogenesis, and drug resistance	[28]
Lung cancer	up	Integrin α9β1	Leukocyte-specific receptors	Promote tumor growth and metastasis	[29]
Lung cancer	down	Integrin α8β1	RGD receptors	Negatively related to tumor progression	[30]
Colon cancer	up	Integrin α2β1	Collagen-binding receptors	Promote tumor growth and liver metastasis	[31]
Glioblastoma	up	Hsc70 – integrin α5β1	RGD receptors	Enhance invasion	[32]

ISSN: 1479-5876