Fig. 1
From: The characteristics and the multiple functions of integrin β1 in human cancers
Framework diagram of cellular signaling triggered by integrin β1 in tumor microenvironment. During the cell adherence to ECM, integrin β1 activity undergoes conformational changes that induce cellular signaling including “inside-out” signal in which signals from inside the cell activate the integrin for binding to the extracellular ligands and “outside-in” signal in which extracellular ligand interaction activates integrin receptor by separating the integrin cytoplasmic domain triggering the intracellular signaling molecules