Fig. 6

DMF reduces symptomatic seizures in rats with chronic epileptic animals. A Normalized seizure frequency (per week, mean ± SEM) in epileptic animals treated with either DMF (200 mg/kg/day for 7 days (shaded area), blue; n = 9 animals) or vehicle (equivalent doses of DMF; n = 9). Data were analyzed using a generalized log-linear mixed model followed by the Sidak post-hoc test. Time effect: P < 0.0001, F (13, 208) = 4.514; Treatment effect: P = 0.018, F (1, 16) = 6.947, Treatment × Time interaction effect: P = 0.0009, F (13, 208) = 2.833. * < 0.05 for comparison between groups at each time point. B Normalized cumulative number of seizures in animals in A. The number of seizures was normalized to the average number before treatment. C Total number of seizures at week 10 post-treatment of animals in a, normalized to baseline = 0.018, Student’s unpaired t-test