Fig. 5

DMF reverses SE-associated behavioral changes in rats. Behavioral analysis of sham and KA-SE rats treated with vehicle or DMF in the open field (A), elevated plus-maze (B), and T-maze spontaneous alteration tests. A1 Representative path of locomotion illustrating average activity in each group. A2, A3 Distance traveled (cm) in the whole arena (A2) and percentage of time spent in the center (A3) during the 5-min testing sessions. B1 Number of entries into the open arms of the EPM for sham animals and rats subjected to KA-SE and treated with vehicle or DMF. B2 Time (%) spent in the open arms by animals from B1. C1 Schematic drawing depicting the experimental setup used in the T-Maze spontaneous alteration T-maze paradigm. C2 Spontaneous alternation rate in sham-operated animals and animals subjected to KA-SE and treated with vehicle or DMF. The number of animals for each group was n = 9. Data are expressed as the mean ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001 after one-way ANOVA followed by Tukey’s post hoc test