Fig. 6

m6A methylation regulates ubiquitin proteasome system. A Expression analysis of ubiquitin proteasome related genes. The heat map on the left showed the expression changes of the ubiquitin proteasome related genes with differential m6A methylation during muscle atrophy. The orange column in the right figure represented the correlation between gene m6A modification and gene expression, while the blue column represented the p-value corresponding to the correlation. B The effects of Daa and R-2HG on the levels of two E3 ubiquitin ligases (Trim63 and Fbx32). Tubulin was used as a loading control, p-value calculated through unpaired t-test, n = 5, *p < 0.05, **p < 0.01, ****p < 0.0001