Fig. 1

m6A features of pre-atrophic skeletal muscle. A A schematic diagram for the construction of the denervation-induced muscle atrophy model and MeRIP-seq library. B The proportion of genes with and without m6A methylated modification in pre-atrophic skeletal muscle. C, D The distribution of m6A peaks in various regions of mRNA transcripts. E The Venn diagram of m6A modified genes across transcription regions. F The distribution of m6A modification on different chromosomes. G The correlation analysis between the expression level of methylated transcripts and m6A in 3′ UTR. The x-axis represents the m6A enrichment multiple of log2 conversion, and the y-axis represents the read numbers of transcripts that undergos log2 conversion. H. Correlation analysis between the expression levels of transcripts containing methylation modifications and m6A in 5′ UTR and CDS. I. The functional analysis of 3′ UTR containing methylation modified genes. The darker the color, the higher the significance of this pathway. J. The functional analysis of 5′ UTR and CDS containing methylation modified genes