Fig. 5

Caprin-1 induces T cells and macrophage infiltration in PDAC. A Visualization of tumor area (PCa), cancer-associated fibroblasts (CAFs), tertiary lymph nodes (TLN) and para-tumor area (PARA) in spatial level. B Volcano plot showing differential genes in PCa between Caprin-1^low and Carpin-1^high tissues. C Volcano plot showing differentially expressed genes in CAFs. D Volcano plot showing different genes in TNLs. E Volcano plot showing differentially expressed genes in TNLs. F The regulatory network generated by gene signatures identified from PCa. G The regulatory network generated by different genes found in CAFs. H The regulatory network generated by gene signatures identified from TLN. I The top enriched functions and gene signatures associated with T cell differentiation, positive regulation of macrophage and T cell activation in PCa, CAFs and TLN. J, K Relative levels of CD4 and CD8 between Carpin-1^high and Caprin-1^low tissues