Table 1 Regulation of tumor malignancy corresponding to Cardio-miRNAs

miR-16

Circulation

↑,↓

ICM, AS, CAM

[101, 115]

LUAD, HCC

NSCLC

TFAP2A/PSG9/TGF-β

LDH-A/lactate/NF-κB

[131, 160, 184]

miR-19a

Circulation

↑

AMI, CAD

[90, 91]

GC, HCC

GC

UC

ccRCC

PTEN/PI3K/AKT

SMAD2/Wnt/β-catenin

Bim—apoptosis

PTEN/SMAD4

[54,55,56,57, 103, 152]

miR-19b

Circulation

↑

HF, AMI, AS

[142,143,144]

NSCLC

CRC

BCL2L11/PPP2R5E

SMAD4, Bim—apoptosis

[103, 152, 153, 185]

miR-21

Circulation

↑

ASO, CAD, HF, AMI

[97, 116, 117, 186]

UC, HCC, NSCLC, CRC, GBM, ccRCC

CRC

RCC

PC

PTEN/PI3K/AKT

PTEN/Akt/IKKβ

PTEN/Akt/NF-ĸB

p53/p21-cyclin E2-Bax/caspase-3

FASL

[57,58,59,60,61,62, 134, 154, 156, 187]

miR-25

Circulation

↑

HF

[188, 189]

TNBC, RBM,

BC, HCC

CCA

BTG2/AKT/ERK/MAPK

PTEN/AKT, MEK4/JNK1

TRAIL

[63, 64, 77, 155, 190]

miR-27a

Circulation

↑

CAD, HF, AMI

[92,93,94]

RCC

NSCLC

GC

TNBC

TXNIP

SMAD2/SMAD4

PHLPP2/AKT

GSK-3β/Wnt/β-catenin

[76, 104, 161, 191]

miR-29a

Circulation

↑

HCM, CHD

[95, 96]

AB

CTNNBIP1/Wnt/β-catenin

[192]

miR-30d

Circulation

↑

HF, AMI

[94, 193]

PC

MYPT1/c-JUN/VEGFA

[168]

miR-92a

Circulation

↑

CAD, CAV

[97, 98]

HCC, NSCLC

SCCOT

OC

CRC

PTEN/PI3K/AKT

DKK1/ Wnt/β-catenin

PTEN

[65, 66, 105, 194]

miR-92b

Circulation

↑

HF, CAD, PH

[195,196,197]

GC

SCLC, GBM

DAB2IP/PI3K/AKT

PTEN/AKT

[67, 78, 198]

miR-106b

Circulation

↑

CAD, HF

[145, 146]

BC, CRC

HCC

CRC

ccRCC

PTEN/PI3K/AKT

GPM6A/DYNC1I1/AKT/ERK

p21

TRIM8/p21

[68, 69, 82, 158, 199]

miR-126

Circulation

↓,↑

AMI, AS,

IHD, SA, UA

[126, 147,148,149,150,151]

ccRCC

BALL

SLC7A5/mTOR-HIF

p53

[157, 200, 201]

miR-130b

Circulation

↑

MI/R, RCVS

[99, 100]

BC, OS, RCC

ES

ccRCC

NSCLC

PTEN, PTEN/AKT

ARHGAP1/CDC42/PAK1/AP1

WNK, TCF4

PTEN/Wnt-β-catenin

[70,71,72,73, 169, 202]

miR-133a

Circulation

↓,↑

CAD, ACS, AMI

[102, 186]

OS

OC

Bcl-xL/Mcl-1

PYGB/Wnt-β-catenin

[106, 159]

miR-146a

Circulation

↑,↓

AMI, ACS, HF, CAD

[94, 118,119,120]

NSCLC

TRAF6/NF-ĸB/p65

[135]

miR-146b

Circulation

↑

MI, PH, HF

[121, 122]

TC

BC

ccRCC

PTEN/PI3K/AKT

AUF1/ETS2/MMP2

TRIM2, TRAF6

[74, 79, 80, 203]

miR-150

Circulation

↓,↑

PH, HF, AMI

[123,124,125]

NSCLC

FOXO4/NF-ĸB/Snail

[132]

miR-155

Circulation

↑

AS, DCM

[126, 127]

MM

ccRCC

BC

CRC

SOCS1/JAK2/STAT3

IGF1R/PI3K/AKT

RKIP

PPP2CA/AKT/NF-κB

[81, 134, 204, 205]

miR-208

Circulation

↑

CAD, ACS, AMI

[186, 206, 207]

PC

HCC

E-Cadherin/PI3K/AKT/ GSK-3β

ARID2/IFITM1

[163, 208]

miR-200a

Circulation

↑

HCM, SCA

[209, 210]

BC

Dicer/miR-16/JNK2/MMP-2 axis

[211]

miR-210

Circulation

↑

PH, HF, CAD

[91, 129, 130]

PC

NSCLC

OC

OCS1/TNIP1/p65/NF-κB

UPF1/PTEN/PI3K/AKT

EphrinA3-PI3K/AKT

[75, 212, 213]

miR-223

Circulation

↑

AS, AMI, SC, AD

[143, 214, 215]

ccRCC

SLC4A4, HIF-2α

[216, 217]

miR-423

Circulation

↑

AMI, HF

[94, 128]

GBM

PC

BC

ING-4/AKT/ERK

GREM2/TGF-β, CREBZF

TNIP2/NF-ĸB

[133, 162, 166, 167]

miR-451

Circulation

↓

PH, AMI

[143, 218]

ccRCC

PSMB8

[219, 220]