Fig. 2

The genetic alteration landscape of SIX1. A, B Schematic diagrams depicting the proportion and type of genetic alterations of SIX1 in breast cancer patients and breast cancer subclasses, respectively, in cBioportal database. C Oncoplot shows the somatic landscape of breast tumor cohort. Genes are ordered by their mutation frequencies, samples are ordered by expression of SIX1, as indicated by the annotation bar (bottom). Side bar plot shows the -log10-transformed q-values, as estimated using MutSigCV. Waterfall plot shows mutation information for each gene for each sample. Color annotation of various cancer types are shown at the bottom. The barplot above the legend shows the number of mutation burden. D and E. Cohort summary plot shows the distribution of variants according to variant classification, and SNV class. F Stacked bar graph shows the top ten mutated genes