From: Integrating cfDNA liquid biopsy and organoid-based drug screening reveals PI3K signaling as a promising therapeutic target in colorectal cancer
Organoid
PIK3CA status
DNA
cDNA change
AA change
Allele frequency
CRC-1
Mutated
chr3 179,218,294
G to A
c.G1624A
p.E542K
57.5%
CRC-2
Wildtype
–
CRC-2T2