Fig. 1From: Anaplastic thyroid cancer cells reduce CD71 levels to increase iron overload toleranceMechanisms of ferroptotic cell death. Ferroptosis could be caused by the inhibition of system Xc− or GPX4 activity, or by iron overload which, through lipid peroxidation, lead to ferroptotic cell death. FAC ferric ammonium citrate, GPX4 glutathione peroxidase 4, GSH glutathione, GS-SG glutathione disulfide, PUFA polyunsaturated fatty acids, RSL3 RAS-selective lethal 3Back to article page