Fig. 9

Schematic diagram illustrating the mechanism. lncRNA-XR_002792574.1 may be involved in the development of myopia through miR-760-3p/Adcy1 pathway in RGCs. On the one hand, lncRNA-XR_002792574.1 might inhibited the cGMP/PKG and Apelin signaling pathways in RGCs through miR-760-3p/Adcy1, thereby causing RGCs damage in myopia. On the other hand, lncRNA-XR_002792574.1/miR-760-3p/Adcy1 axis may cause myopic scleral remodeling through the ERK-MMP-2 pathway. RGCs: retinal ganglion cells