Fig. 6

Assessment of FDM model and further validations of miR-760-3p/Adcy1 in mice. A Refraction in mice at two time points (n = 9). B Representative image of the axial length (AL) in mice. C AL in mice at two time points (n = 9). D Morphological observation with H&E-stained retinas in mice (scale bar: 50 µm) (n = 5–6). E The targeting relationship between miR-760-3p and Adcy1 was predicted. F The relative expressions of lncRNA-XR_377380.2 (homologue of guinea pig lncRNA-XR_002792574.1) were measured by qRT-PCR. G The relative expressions of miR-760-3p were measured by qRT-PCR. H The relative expressions of Adcy1 mRNA were measured by qRT-PCR. I IOD analysis of Adcy1 expression in RGCs from mice. J Images of Adcy1 (red) immunofluorescence in retina from mice with nucleus (blue) (scale bar: 20 µm). ^*P < 0.05, ^**P < 0.01, ^***P < 0.001. NCG: normal control group; FDMG fellow: form-deprived myopia fellow control group; FDMG: form-deprived myopia group