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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Transcription factor LHX9 (LIM Homeobox 9) enhances pyruvate kinase PKM2 activity to induce glycolytic metabolic reprogramming in cancer stem cells, promoting gastric cancer progression

Fig. 6

Nude Mouse Subcutaneous Tumor Model to Validate the Effect and Mechanism of LHX9 on Tumor Growth and Glycolytic Reprogramming. A: comparison of subcutaneous transplantation tumor mass in each group of nude mice; B: comparison of subcutaneous transplantation tumor volume in each group of nude mice; C: comparison of subcutaneous transplantation tumor mass in each group of nude mice; D: comparison of lactate expression in subcutaneous transplantation tumor tissue in each group of nude mice; E: comparison of ATP content in subcutaneous transplantation tumor tissue in each group of nude mice; F: comparison of glycolysis-related genes (GLUT1, HK2, LDHA F: Comparison of mRNA and protein expression of glycolysis-related genes (GLUT1, HK2, LDHA, and PDK1) in subcutaneous transplanted tumor tissues of nude mice in each group; *: P < 0.05, statistically significant between groups; An independent samples t-test was used to compare the two groups, and a repeated ANOVA was employed to analyze the tumor data at different time points (N = 10)

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Journal of Translational Medicine

ISSN: 1479-5876

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