Fig. 4

Therapeutic implications of the association between m6A regulators and the PI3K/AKT signalling pathway. The METTL3, METTL14, and ALKBH5 proteins, which are regulators of the m6A modification in RNA molecules, have been shown to have the ability to modulate the activity of the PI3K/AKT signaling pathway in different types of cancer. This regulation results in a consequential impact on the progression, metastasis, and proliferation of the cancer cells, thus indicating a desirable avenue for therapeutic optimization. Image created with BioRender (https://biorender.com/)