Table 1 Baseline characteristics of participants
From: Multipredictor risk models for predicting individual risk of Alzheimer’s disease
CN (n = 487) | MCI (n = 796) | ||||
|---|---|---|---|---|---|
ADNI 1 | ADNI 2 | ADNI 1 | ADNI 2 | ADNI GO | |
n | 214 | 273 | 360 | 317 | 119 |
Number of events | 72 | 67 | 206 | 96 | 19 |
Follow-up period (years) | 5.1 (3.3) | 3.8 (1.9) | 4.84 (3.1) | 3.9 (1.8) | 5.3 (2.0) |
Age (years) | 75.9 (5.1) | 73.0 (6.0) | 74.8 (7.3) | 70.5 (7.3) | 71.85 (8.9) |
Sex (F/M) | 103/111 | 147/126 | 129/231 | 143/174 | 54/65 |
Education (years) | 16.1 (2.8) | 16.6 (2.5) | 15.7 (3.0) | 15.92.6 | 15.17 (2.7) |
APOE ε4 carriers (0/1/2) | 156/54/4 | 189/78/6 | 167/150/43 | 157/123/37 | 70/41/8 |
MMSE | 29.1 (1.0) | 29.0 (1.2) | 27.1 (1.8) | 28.1 (1.7) | 28.3 (1.7) |
ADAS11 | 6.1 (3.0) | 5.7 (2.9) | 11.42 (4.4) | 9.3 (4.6) | 7.5 (3.3) |
RAVLT immediate | 43.7 (9.0) | 45.6 (10.3) | 31.0 (9.2) | 39.7 (11.1) | 42.39 (11.1) |
FAQ | 0.14 (0.6) | 0.3 (1.1) | 3.8 (4.5) | 2.6 (3.8) | 1.0 (1.7) |
LM-DR | 13.0 (3.5) | 13.3 (3.1) | 3.9 (2.7) | 6.2 (3.4) | 8.3 (1.8) |
Plasma tau (pg/ml) | 2.7 (1.6) | NA* | 2.9 (1.7) | NA* | NA* |
Plasma NFL (pg/ml) | 35.1 (22.0) | 29.0 (7.8) | 42.6 (27.8) | 38.3 (17.9) | 38.8 (21.3) |
White matter hyperintensities (mm3) | 0.8 (2.2) | 6.3 (10.6) | 0.8 (2.5) | 6.2 (8.3) | 7.5 (10.0) |
Hippocampus volume (cm3) | 7.2 (0.9) | 7.6 (0.8) | 6.4 (1.0) | 6.9 (1.1) | 7.2 (1.0) |
Whole brain volume (cm3) | 1004.0 (55.5) | 1073.4 (64.2) | 977.5 (63.9) | 1046.4 (64,3) | 1069.6 (50.8) |
Entorhinal volume (cm3) | 3.8 (0.7) | 3.9 (0.6) | 3.3 (0.7) | 3.5 (0.7) | 3.7 (0.6) |
Middle temporal lobe volume (cm3) | 19.6 (2.1) | 21.0 (2.3) | 18.5 (2.5) | 19.8 (2.4) | 20.8 (2.1) |
Ventricles volume (cm3) | 35.2 (16.6) | 35.2 (16.6) | 41.2 (20.2) | 38.2 (18.7) | 38.0 (19.3) |
CSF Aβ (pg/ml) | 207.6 (52.0) | 198.2 (49.7) | 199.0 (52.1) | 175.4 (51.5) | 192.2 (48.4) |
CSF tau (pg/ml) | 69.0 (26.3) | 66.2 (32.9) | 100.5 (52.2) | 98.4 (52.5) | 84.2 (58.7) |
CSF p-tau (pg/ml) | 26.4 (14.2) | 35.2 (19.2) | 35.82 (22.8) | 45.6 (25.1) | 34.2 (19.8) |
BMI | 26.4 (4.5) | 27.7 (5.0) | 25.99 (4.0) | 27.3 (5.2) | 28.3 (5.6) |
Cholesterol (mg/dl) | 193.2 (40.4) | 190.9 (39.4) | 197.4 (39.2) | 208.0 (37.1) | 210.4 (39.7) |
Systolic blood pressure (mmHg) | 132.9 (16.0) | 133.8 (16.0) | 133.1 (17.0) | 130.1 (17.6) | 134.8 (18.2) |
History of diabetes (%) | 13 (6.1%) | 25 (9.2%) | 24 (6.7%) | 33 (10.4%) | 12 (10.1%) |
History of hypertension (%) | 96 (44.9%) | 127 (46.5%) | 176 (48.9%) | 147 (46.4%) | 56 (47.1%) |
History of depression (%) | 35 (16.4%) | 59 (21.6%) | 103 (28.6%) | 118 (37.2%) | 29 (24.4%) |