Table 2 Characteristics of fibrotic versus non-fibrotic lung nodules
From: Comparison of lung cancer occurring in fibrotic versus non-fibrotic lung on chest CT
Description | Fibrotic lung nodule (N = 274) | Non-fibrotic lung nodule (N = 335) | *p-value | |
|---|---|---|---|---|
Demographics | Age at first CT | 70 (22–95) | 66 (25–93) | < 0.01 |
Gender (male) | 137/274 (50%) | 156/335 (47%) | 0.50 | |
Nodule characteristics | Location | RUL (77) 28% RML (15) 6% RLL (72) 26% LUL (56) 20% LLL (54) 20% | RUL (83) 25% RML (43) 13% RLL (59) 18% LUL (79) 24% LLL (71) 21% | < 0.01 |
Average size(mm) first CT Average size of non-cancer nodules Average size of cancer nodules | 16 mm (0–87 mm) 15 mm (range 3–81 mm) 26 mm (range 2–87 mm) | 10 mm (0–106 mm) 10 mm (range 2–52 mm) 29 mm (range 2–106 mm) | < 0.05 | |
Average size(mm) second CT | 23 mm (0–167 mm) | 11 mm (0–92 mm) | < 0.01 | |
Two CT scans | 217/274 (79%) | 263/335 (79%) | 0.84 | |
No change in size | 78/217 (36%) | 167/263 (63%) | < 0.01 | |
Decrease in size | 15/217 (7%) | 25/263 (10%) | < 0.01 | |
Increase in size | 97/217 (45%) | 48/263 (18%) | < 0.01 | |
New nodule | 27/217 (12%) | 23/263 (9%) | 0.18 | |
Lung cancer | Pathology proven cancer | 93/274 (34%) | 50/335 (15%) | < 0.01 |
Squamous cell carcinoma | 30/93 (32%) | 7/50(14%) | 0.02 | |
Adenocarcinoma | 36/93 (39%) | 30/50 (60%) | 0.13 | |
Small cell lung cancer | 15/93 (16%) | 5/50 (10%) | 0.31 | |
Other cancer | 12/93 (13%) | 8/50 (16%) | 0.05 |