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Table 2 Overall outcomes of the first and cumulative transplant between PGT-A and non-PGT-A patients

From: Exploring the efficacy and beneficial population of preimplantation genetic testing for aneuploidy start from the oocyte retrieval cycle: a real-world study

 

PGT-A

Non-PGT-A

OR (95%CI)

P value

Number of oocyte retrieval cycles

4195

10,140

  

Number of first transfer cycles

1844

7334

  

Single embryo transfer

99.0% (1825/1844)

21.8% (1,599/7334)

344.50 (225.26–562.89)

 < 0.001

Live birth rate

52.6% (970/1844)

34.2% (2,511/7334)

2.13 (1.92–2.36)

 < 0.001

Singleton

52.0% (959/1844)

26.9% (1,975/7334)

2.94 (2.65–3.27)

 < 0.001

Multiple

0.6% (11/1,844)

7.3% (536/7334)

0.08 (0.04–0.13)

 < 0.001

Clinical pregnancy rate

63.9% (1,178/1844)

46.9% (3437/7334)

2.01 (1.81–2.23)

 < 0.001

Singleton

62.5% (1,152/1844)

34.4% (2,522/7,334)

3.18 (2.86–3.53)

 < 0.001

Multiple

1.4% (26/1844)

12.5% (915/7,334)

0.10 (0.07–0.15)

 < 0.001

Pregnancy loss rate

17.7% (208/1178)

26.9% (926/3,437)

0.58 (0.49–0.69)

 < 0.001

Ectopic pregnancy

0.9% (11/1178)

2.1% (71/3,437)

0.45 (0.22–0.81)

0.011

Early miscarriage

12.8% (151/1178)

20.2% (694/3,437)

0.58 (0.48–0.70)

 < 0.001

Late miscarriage

4.0% (47/1178)

4.7% (161/3,437)

0.85 (0.60–1.17)

0.322

Pregnancy complications

33.3% (392/1178)

29.5% (1,014/3,437)

1.19 (1.03–1.37)

0.015

Gestational hypertension rate

4.1% (48/1178)

3.2% (111/3,437)

1.27 (0.89–1.79)

0.171

Gestational diabetes rate

17.4% (205/1178)

13.2% (453/3,437)

1.39 (1.16–1.66)

 < 0.001

Preterm birth ratea

8.6% (83/970)

17.3% (432/2,502)

0.45 (0.35–0.57)

 < 0.001

Singletona

8.0% (77/959)

8.6% (169/1,970)

0.93 (0.70–1.23)

0.615

Multiplea

54.5% (6/11)

49.4% (263/532)

1.23 (0.37–4.30)

0.738

Low birth weight ratea

4.9% (48/972)

19.3% (579/3005)

0.22 (0.16–0.29)

 < 0.001

Singletona

4.0% (38/950)

4.8% (94/1950)

0.82 (0.55–1.20)

0.320

Multiplea

45.5% (10/22)

46.0% (485/1055)

0.98 (0.41–2.29)

0.962

Neonatal malformation cycle rate

0.9% (9/970)

2.0% (50/2511)

0.46 (0.21–0.90)

0.029

Cumulative number of transfer cycles

2258

9365

  

Cumulative number of newborns

1175

3818

  

Cumulative live birth rateb

27.5% (1155/4195)

31.1% (3150/10,140)

0.84 (0.78–0.91)

 < 0.001

Singleton

27.2% (1141/4195)

24.7% (2508/10,140)

1.14 (1.05–1.23)

0.002

Multiple

0.3% (14/4195)

6.3% (642/10,140)

0.05 (0.03–0.08)

 < 0.001

Interval since oocyte retrieval, daysa

395 (348–473)

263 (254–347)

–

 < 0.001

Number of cycles not reached live birth

3,040

6,990

  

Oocyte unretrieved cycle rate

6.0% (251/4195)

6.4% (654/10,140)

0.92 (0.79–1.07)

0.296

No transferable embryo cycle ratec

42.7% (1793/4195)

22.5% (2281/10,140)

2.57 (2.38–2.78)

 < 0.001

With transferable embryo cycle rated

10.1% (423/4195)

16.5% (1671/10,140)

0.57 (0.51–0.64)

 < 0.001

  1. CI confidence interval, Non-PGT-A not use preimplantation genetic testing for aneuploidy, OR odds ratio, PGT-A preimplantation genetic testing for aneuploidy
  2. aThe missing conditions of these indicators in the PGT-A group and non-PGT-A group are as follows: 0/970 vs. 9/2511, 0/959 vs.5/1970, 0/11 vs.4/532, 9/981 vs. 45/3050, 9/959 vs. 25/1970, 0/22 vs. 20/1075, 9/1150 vs. 27/3143;
  3. bTwice or more live births under the same oocyte retrieval cycle are counted as one when the cumulative live birth rate is calculated. The numbers of twice live births in the PGT-A group and non-PGT-A group were 6 and 23, respectively;
  4. cThe proportion of abnormal embryos (including chimeras) detected in the PGT-A group was 23.0% (965/4195);
  5. dThe undetected transferable embryos were included in the PGT-A group;
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Journal of Translational Medicine

ISSN: 1479-5876

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