Fig. 6

Function of DRAM1 in related cell clusters. A Functional annotation of DRAM1-related genes. B GSEA of glycolysis-related genes in C10_ULK1 comparing controls and septic patients. C Two-dimensional plots show the correlation between DRAM1 and GAPDH, glycolysis-related genes (from “HALLMARK_GLYCOLYSIS”). D The bar chart shows the expression level of LDHA in controls and E. coli septic patients. E Volcano plots depict the differential metabolites between bacterial sepsis and controls. F The 2D image displays the RNA density (left) and the distributions of DRAM1 and P4HB in cells (right). G The ridgeline plot shows the expression level of ELF1 in C10_ULK1 between controls and septic patients. H ELF1 ChIP-seq peaks at the promoter regions of DRAM1. I The schematic diagram shows the regulatory molecular mechanism of DRAM1 in C10_ULK1 in E. coli sepsis