Fig. 2

Dysregulated features of E. coli sepsis. A Volcano plots depict the DEGs between E. coli sepsis and controls in each bulk dataset. B The venn diagram illustrates the relationship of DEGs from various datasets. C The circle heatmap displays the expression of 143 underlying key genes of E. coli sepsis in each dataset. D and E Bar graph of enriched terms in biological function D and cell type signatures E across the 143 genes, colored by Q values. F The venn diagram (left) depicts the relationship of DEGs from ex vivo whole blood infection with E. coli and E. coli sepsis, a bar graph (right) shows the enriched terms across 212 genes, colored by Q values. G The heatmap shows the common and specific function terms across all types