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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Advanced glycation end products impair bone marrow mesenchymal stem cells osteogenesis in periodontitis with diabetes via FTO-mediated N6-methyladenosine modification of sclerostin

Fig. 2

Overview of m6A methylation patterns in alveolar bone of normal and diabetes. A, B Venn diagram showing the overlap of m6A peaks number in two groups represents the m6A modification changes (A) and gene modification changes (B). The quantity of control-unique, DM-unique and common of m6A peaks and m6A-regulated genes are shown respectively. C The conserved consensus RGACU of m6A motif was identified in both control and DM groups. D Density curve depicts the distribution of m6A peaks along transcripts of two groups. E Percentage of genes with different numbers of m6A peaks in two groups. F Distribution of m6A peaks in the functional region of transcripts. The pie chart depicts the proportion distribution of m6A peaks on each region (top), and the histogram depicts the enrichment ratio of m6A peaks on the corresponding element (bottom)

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