Table 1 Patient characteristics
Characteristic | Overall (955) | Training cohort (671) | Validation cohort (284) | p-value |
|---|---|---|---|---|
Basic information | ||||
Age (year) | 63.07 (10.89) | 62.89 (10.98) | 63.50 (10.71) | 0.424 |
Sex (n) | 0.881 | |||
Male | 630 (66%) | 444 (66%) | 186 (65%) | |
Female | 325 (34%) | 227 (34%) | 98 (35%) | |
Weight(kg) | 62.93 (10.72) | 62.53 (10.84) | 63.88 (10.39) | 0.071 |
Height(m) | 1.65 (0.08) | 1.65 (0.08) | 1.65 (0.08) | 0.883 |
BMI(kg/m2) | 23.00 (3.20) | 22.84 (3.22) | 23.37 (3.12) | 0.018 |
BSA | 1.69 (0.17) | 1.69 (0.17) | 1.71 (0.17) | 0.125 |
Location(n) | 0.724 | |||
Colorectum | 483 (51%) | 342 (51%) | 141 (50%) | |
Stomach | 472 (49%) | 329 (49%) | 143 (50%) | |
Ratio of body weight loss | 0.02 (0.05) | 0.02 (0.05) | 0.02 (0.05) | 0.933 |
CCR(umol/mg) | 77.79 (13.23) | 77.91 (13.12) | 77.52 (13.51) | 0.688 |
Cre(umol/L) | 75.66 (14.98) | 75.58 (14.96) | 75.85 (15.05) | 0.797 |
CysC(mg/L) | 0.98 (0.17) | 0.98 (0.16) | 0.99 (0.17) | 0.387 |
TNF(ng/ml) | 17.04 (23.12) | 16.73 (21.93) | 17.78 (25.74) | 0.549 |
CRP(mg/L) | 6.24 (15.87) | 5.97 (15.12) | 6.88 (17.53) | 0.448 |
BUN(mmol/L) | 5.24 (1.52) | 5.26 (1.48) | 5.18 (1.62) | 0.490 |
GLU(mmol/L) | 5.58 (1.47) | 5.57 (1.48) | 5.59 (1.45) | 0.905 |
ALB(g/L) | 41.08 (4.27) | 41.13 (4.30) | 40.95 (4.20) | 0.558 |
NEUT(× 109/L) | 3.39 (1.61) | 3.36 (1.66) | 3.47 (1.48) | 0.331 |
LYMPH(× 109/L) | 1.66 (0.57) | 1.67 (0.56) | 1.64 (0.57) | 0.347 |
HGB(× 1012/L) | 122.64 (23.49) | 122.71 (23.18) | 122.47 (24.26) | 0.888 |
WBC(× 109/L) | 5.72 (1.93) | 5.69 (1.98) | 5.78 (1.82) | 0.516 |
PLT(× 109/L) | 234.38 (80.98) | 234.14 (79.79) | 234.94 (83.88) | 0.892 |
Imaging indices | ||||
SMI(cm2/m2) | 46.49 (7.70) | 46.35 (7.50) | 46.80 (8.14) | 0.423 |
IMAT% | 6.84 (5.54) | 6.54 (3.96) | 0.08 (0.08) | 0.047 |
IMAT(cm2) | 7.98 (4.51) | 7.84 (4.31) | 8.33 (4.93) | 0.146 |
SMD (HU) | 32.94 (6.30) | 33.16 (6.17) | 32.42 (6.60) | 0.109 |
SMA(cm2) | 127.68 (26.41) | 127.31 (26.04) | 128.55 (27.29) | 0.517 |
SMG(AU) | 1548.76 (446.56) | 1552.87 (434.00) | 1539.04 (475.57) | 0.674 |
Clinical outcomes | ||||
Cachexia(n) | 0.531 | |||
No | 771 (81%) | 538 (80%) | 233 (82%) | |
Yes | 184 (19%) | 133 (20%) | 51 (18%) | |
Sarcopenia(n) | 0.627 | |||
No | 710 (74%) | 502 (75%) | 208 (73%) | |
Yes | 245 (26%) | 169 (25%) | 76 (27%) | |
Myosteatosis(n) | 0.080 | |||
No | 596 (62%) | 431 (64%) | 165 (58%) | |
Yes | 359 (38%) | 240 (36%) | 119 (42%) | |
Death(n) | 0.507 | |||
No | 663 (95%) | 476 (95%) | 187 (94%) | |
Yes | 36 (5%) | 24 (5%) | 12 (6%) | |
Missing | 256 | 171 | 85 | |
Progression(n) | 0.878 | |||
No | 615 (89%) | 435 (90%) | 180 (90%) | |
Yes | 73 (11%) | 51 (10%) | 22 (10%) | |
Missing | 267 | 185 | 82 | |
OS(day) | 0.565 | |||
1110.37 (298.77) | 1114.47 (299.79) | 1100.09 (296.72) | ||
Missing | 256 | 171 | 85 | |
PFS(day) | 0.772 | |||
1085.58 (308.08) | 1087.74 (308.12) | 1080.22 (308.71) | ||
Missing | 267 | 181 | 86 | |