Fig. 4
RT2 Profiler PCR Array Mouse Mitochondria Data (Heart). Heat-map displays of all 30 transcripts found to be significantly altered between BTHS and WT samples amongst the 84 assessed in the mitochondrial transcription array. A Heat map (green/red) display of average fold change for each transcript as compared to WT controls with each cohort in a separate row. B Heat map (yellow/purple) -Log10 p-values depicting the extent of significant difference for each cohort in a separate row as compared to WT controls. A total of 30 genes were found to be significantly downregulated in the BTHS heart as compared to age-matched healthy controls. C Venn diagram depiction of the number of genes that were corrected in the respective treatment groups. D A bar plot showing number of genes involved in the listed biological processes generated with ShinyGO 0.77 using the list of 19 genes that were corrected in both treatment groups. Profile arrays were run in quadruplicate for each of 3 samples from each cohort. (p ≤ 0.05 was considered to be a significant difference as compared to WT)