Fig. 7

HOTAIRMI silencing partially reverses METTL3-dependent U251 cell malignancy. A CCK-8 assay was used to detect glioma cell proliferation in indicated transfected groups. B–C Transwell assay was conducted to evaluate glioma cell migration and invasion capabilities in indicated transfected groups (Scale bar = 50 μm). D VM formation capacity in indicated transfected groups was assessed by Tube-formation assay (Scale bar = 100 μm). Data are presented as the mean ± SD of three independent experiments (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001