Fig. 3
From: RIZ2 at the crossroad of the EGF/EGFR signaling in colorectal cancer
Impact of RIZ2 overexpression on gene expression in DLD1 CRC cells. A MA plot showing transcriptome changes, measured by RNA sequencing (RNA-seq), following RIZ2 overexpression. B Heatmap showing top 100 down-regulated (blue) and up-regulated (red) transcripts following RIZ2 overexpression. (fold-change ≤ and ≥|1.5|, adj p-value < 0.05). Data are shown as normalized expression values in log2 scale and centered on the median value. C Bar Chart obtained by IPA (Ingenuity Pathway Analysis) functional annotation analysis showing statistically significant molecular function enriched following RIZ2 overexpression