From: Meningioma animal models: a systematic review and meta-analysis
Cell line/WHO-gr | ToA mice | Age (w) | NoC/IV | DoI (d) | TTR %(pooled animals) | IVoG | NIVoG | PuCL |
---|---|---|---|---|---|---|---|---|
Orthotopic models | ||||||||
 IOMM-Lee/malignant | Athymic nu/nu [24, 49, 54, 66, 70, 74, 77, 80], SCID [44, 55], Nude [45, 68, 74, 78, 82, 83], Swiss nude [47, 53, 59, 61, 62, 79, 81], BALB/c [50, 58, 84], NOD(shi-SCID,IL-2Rgamma(null,c)(NOG) [60], CD1 [67], NCr-Foxn1 (nu) [85] | 3 [67], 4–10 [24, 44, 45, 49, 50, 54, 55, 58,59,60,61, 66, 74, 77,78,79, 81,82,83,84,85], > 9 [47], 12–15 [62], 10–22 [53], | (104) [49], (5 × 104) [60, 66, 83], (105) [50, 62, 67, 78, 82], (1.5 × 105) [58], (2 × 105) [85] (2.5 × 105) [47, 53, 54, 59, 61, 79, 83, 84], (4 × 105) [45], (5 × 105) [66,67,68, 70, 75], (106) [24, 44, 74, 77, 81], (3 × 106) [66]/(0.5) [66, 83], (1) [66], (2) [62, 84] (2.5) [47, 53, 79, 83], (3) [50, 58, 60, 66, 67, 77], (5) [54, 59, 61, 66, 81], (3–10) [44], (10) [24, 68, 74, 78, 82] | CD (4–12) [24], (5) [60], (9) [61], (10) [59, 60], (11) [53], (14) [58, 60, 62, 67, 74, 81], (21) [78], (28) [75] SS (10) [60, 66], (11) [85], (12) [66], (13) [77], (15) [53], (17) [47, 66], (20) [66, 79], (21) [49, 84], (23) [50], (27) [45], 15–21 [83] | 100% (504/504) [24, 45, 50, 53, 58,59,60,61,62, 66,67,68, 70, 75, 77,78,79, 81, 82, 84] | Histology [24, 44, 45, 47, 50, 53, 54, 60,61,62, 66,67,68, 70, 74, 75, 77,78,79, 81, 82, 84, 85] | 29 [24, 44, 45, 47, 49, 50, 53, 54, 58,59,60,61,62, 66,67,68, 70, 74, 75, 77,78,79,80,81,82,83,84,85] a[55] | |
 BEN-MEN-1/benign | (0.5–1.0 × 106) [91], (106) [21, 89, 90]/3–5 [21, 89,90,91,92] CN-ND [55] | CD (35 [90], 98 [89, 92], 107 [21], 180 [91]) ND [55] | ||||||
 CH-157/malignant | (104) [67], (105) [43, 67, 94], (2 × 104) [93], (2 × 105) [85], (5 × 105) [67], (106) [67] | 100% (66/66) [93, 94] 91% (20/22) [98] 90% (45/50) [67] | MRI [98] | |||||
 KT21MG1/malignant | Swiss nude [59, 61], NMRI nu/nu [99], athymic [101], SCID [90] | 5 × 104 [101]; 2.5 × 105 [59, 61]; 5 × 105 [90]; 106 [99] | CD 10 [99], 17 [61], 21 [59], 42 [90] SS 19 [101] | BLI [90] | ||||
 F5 | (2.5 × 105) [107], (106) [81], WT [106]/(5) [81], IV-ND [107] | SS (29) [106] | ||||||
 MN3 | SS 92 [114] ND [113] | – | ||||||
 MN8 | SCID [114] | 7–8 [114] | (5 × 104)(114)/(3) [114] | ND [114] | ND [114] | – | 1 [114] | |
 HKBMM | BALB/C-nu/nu [84] | 6–8 [84] | SS 27 [84] | 100% (24/24) [84] | – | 1 [84] | ||
 Me10T Me3TSC | Athymic [69] | 4 [69] | CD (112) [69] | 100% (6/6) [69] Me10T 100% (6/6) [69] Me3TSC | Histology [69] IHC [69] | – | 1 [69] | |
Heterotopic models | ||||||||
 IOMM-Lee/malignant | Athymic nu/nu [49, 57, 71, 75, 76], BALB/c-nu [22, 46, 48, 51, 52, 56, 84], SCID [55, 63], Swiss nude [59, 61, 62, 83], nude [45, 64, 65, 86, 88], CD1 [20, 72, 73], C57BL/6 [87] | 3 [20, 72, 73], 4–6 [46, 51, 52, 56, 71, 87, 88], 6 [45, 55], 6–8 [49, 64, 65, 76, 84, 86], 8 [22, 48, 58], 8–10 [59, 61, 83], 7–11 [62], ND [57, 63, 75] | (2 × 104) [46], (1.5 × 105) [58], (5 × 105) [20, 46, 72], (106) [57, 63, 71, 73, 76], (1.5 × 106) [20], (2 × 106) [45, 86, 88], (3 × 106) [59, 61, 62, 83], (4 × 106) [64], (5 × 106) [48, 49, 52, 65, 75, 84], (107) [22, 55, 56, 87], (5 × 107) [51]/(3) [58] (100) [46, 48, 55, 58, 59, 61, 63, 72, 73, 75, 76, 83, 84, 86, 87], (200) [22, 51, 88], (500) [20], IV-ND [45, 49, 52, 56, 57, 62, 64, 65, 71] | CD 12 [52], 14 [58, 62, 76], 16 [84], 17 [59], 21 [57, 61, 65, 83], 25 [64, 86], 26 [71], 28 [46, 48, 75, 88], 30 [56], 31 [49], 34 [51], 35 [45], 43 [72], 45 [87], 56 [20, 73] | 100% (432/432) [22, 45, 46, 48, 51, 52, 57,58,59, 61, 62, 64, 65, 71,72,73, 76, 83, 86, 87] 95% (19/20) [20] 87% (13/15) [63] 77% (23/30) [56] | Histology [20, 22, 45, 49, 51, 52, 63, 65, 72, 73, 75] IHC [20, 22, 45, 46, 48, 49, 51, 52, 58, 59, 61, 63,64,65, 71,72,73, 86,87,88] | Caliper [45, 49, 51, 52, 55,56,57,58,59, 61, 62, 64, 71, 72, 76, 83, 84, 86, 87] FI [58] | 28 [20, 22, 45, 46, 48, 49, 51, 52, 55,56,57,58,59, 61,62,63,64,65, 71,72,73, 75, 76, 83, 86, 87] |
 CH-157/malignant | 5–6 [6] | (5 × 105) [72], (106–1.25 × 106) [20], (1.5 × 106) [95,96,97], (3 × 106) [6] | OC 43 [20] | FI [97] | a[88] | |||
 HKBMM | (5 × 105) [102], (106) [102], (5 × 105) [84], 7 × 106) [103], (107) [104]/(100) [84], (200) [102, 103], IV-ND [104] | CD 16 [84], 49 [103], 56 [104], 140 [102] ND [102] | a[84] | |||||
 NCH93 | (106) [110], (4 × 106) [111, 115]/(100) [110, 111], (200) [115] | |||||||
 SF4433 | - | |||||||
 SF3061 | Athymic [109] | 6 [109] | CD 11 [109] | 100% (30/30) [109] | - | Caliper [109] | 1 [109] | |
 KT21MG1/malignant | ICR nu/nu [100] | 4–5 [100] | CD 90 [100] | 100% (3/3) [100] | – | 1 [100] | ||
 F5 | BALC/c [106] | 6 [106] | WT [106] | SS 28 [106] | 100% (40/40) [106] | IHC [106] | – | 1 [106] |
 HBL52 | BALB/c [112] | 7 [112] | CC 49 [112] SS (27) [112] | 100% (96/96) [112] | IHC [112] | Caliper [112] | 1 [112] | |
 KCI-MENG1-LP/HP | SCID/NCr [105] | ND [105] | ND [105] | Serial transplantations [105] | ND [105] | Histology(105) IHC [105] | – | 1 [105] |