Fig. 3

CRIME-Q—Quality of Reporting, Methodological Quality and SYRCLE’s Risk of Bias. Graphical display of all categories 1–10 including all included studies A Quality of Reporting items (X) and Methodological Quality (Y) Green = Yes, Yellow = Partly, Red = No. B Results of Items from SYRCLE’s Risk of Bias tool. Green = Yes, Yellow = Unclear, Red = No, Blue = Not applicable. 1X Peer-review, 2X Bench-top/laboratory work related to establishing model, 2Y Methodological quality of 2X, 3X Animals, 3Y Methodological quality of 3X, 3Z: Selection bias (baseline characteristics), 4Y Sample size, 5X in vivo design and performance, 5Y: Methodological quality of 5X, 5Z(1): Selection bias (Sequence generation), 5Z(2): Performance bias (Random housing), 5Z(3): Detection bias (Random outcome assessment), 6X: Compliance with animal welfare regulations, 7X Blinding, 7Z(1) Performance bias (Blinding), 7Z(2) Allocation bias (allocation concealment), 7Z(3) Detection bias (blinding), 8X Congruency between methods and results, 8Z(1) Attrition bias (incomplete outcome data), 8Z(2) Reporting bias (Selective outcome reporting), 9X Presentation of limitations, 10X Statement of potential conflict of interest, 10Z Other bias (Publication bias). See Table 1 for further descriptions