Fig. 3

Relationship between metastasis of thyroid cancer cells and glycolysis and EMT. Metastasis of thyroid cancer cell is a multistage process including invasion, intravasation, circulation, extravasation, and colonization. Intravasation and extravasation are closely related to glycolysis and the EMT process. One of the reasons for the extremely high risk of thyroid cancer is that it can metastasize remotely through lymph nodes, often to the lungs, bones, liver and brain