Fig. 6

SPOCK1 is associated with invasive properties. In the GSE166722 dataset, (A) SPOCK1 expression levels in invasive phenotype and inert phenotype LUAD. B ROC curves showing the diagnostic efficacy of SPOCK1 in differentiating between aggressive and inert patients. C Differential expression levels of SPOCK1 in different aggressive pathological histological subtypes; (D) Differential expression levels of SPOCK1 in patients with or without lymph node metastasis. E Heatmap of the distribution of SPOCK1 and EMT-related markers in the combined cohort and (F) NSCLC cell lines, and the mesenchymal score and epithelial score were assessed based on the ssSGEA algorithm, and correlations were calculated (spearman test). G The potential association between SPOCK1 and dysregulated oncogenic pathways in the combined cohort and (H) NSCLC cell lines. (***p < 0.001; **p < 0.01; *p < 0.05; ns. no significance.)