Fig. 4

SPOCK1 is associated with adverse clinical outcomes. A–H Prognostic value of SPOCK1 was assessed in the combined cohort and seven independent cohorts. I Heat map of the distribution of SPOCK1 with clinicopathological features. J Differential expression of SPOCK1 in normal and tumor tissues. K Differential expression of SPOCK1 between normal tissues and paired tumor tissues. L Differential expression of SPOCK1 in normal and tumor tissues. L GSEA analysis showing the activation profile of biological pathways in the high SPOCK1 group. (***p < 0.001; **p < 0.01; *p < 0.05; ns. no significance.)