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Fig. 9 | Journal of Translational Medicine

Fig. 9

From: Bufalin targeting CAMKK2 inhibits the occurrence and development of intrahepatic cholangiocarcinoma through Wnt/β-catenin signal pathway

Fig. 9

Bufalin targeting CAMKK2 affects ANXA2's inhibition of ICC occurrence and metastasis and promotion of mitochondrial dysfunction via the Wnt/ β-catenin signaling pathway. Bufalin down-regulates the expression of CAMKK2 in ICC, and then down-regulates ANXA2, reversing the activation of Wnt/β-catenin signaling pathway induced by CAMKK2/ANXA2, inhibiting the occurrence and metastasis of ICC, and promoting mitochondrial dysfunction. The figure is drawn in Figdraw software (www.figdraw.com)

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Journal of Translational Medicine

ISSN: 1479-5876

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