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Table 1 The effects of the GRSLC on CRC and the GRSCRC on LC

From: Bidirectional Mendelian randomization analysis of the genetic association between primary lung cancer and colorectal cancer

Exposure

Outcome

OR (95% CI)

P value

Exposure

Outcome

OR (95% CI)

P value

Overall LC

Overall CRC

1.0026 (1.0012–1.0039)

0.0002

Overall CRC

Overall LC

1.0074 (0.9112–1.1137)

0.89

Colon cancer

1.0014 (1.0005–1.0023)

0.0028

LUSC

1.1206 (0.9096–1.3806)

0.28

Rectal cancer

1.5979 (1.2695–2.0113)

6.53E-05

LUAD

1.0634 (0.8991–1.2577)

0.47

LUSC

Overall CRC

1.0017 (1.0008–1.0026)

0.0002

Colon cancer

Overall LC

1.0080 (0.8989–1.1302)

0.89

Colon cancer

1.0008 (1.0002–1.0014)

0.01

LUSC

1.2085 (0.9525–1.5332)

0.12

Rectal cancer

1.3719 (1.1654–1.6150)

0.0001

LUAD

1.1274 (0.9309–1.3652)

0.22

LUAD

Overall CRC

0.9993 (0.9979–1.0007)

0.3

Rectal cancer

Overall LC

1.0508 (0.9214–1.1984)

0.46

Colon cancer

1.0004 (0.9994–1.0013)

0.47

LUSC

1.1469 (0.8727–1.5072)

0.33

Rectal cancer

0.8882 (0.7156–1.1026)

0.28

LUAD

1.0617 (0.8522–1.3227)

0.59