Fig. 8
From: Palmitoylation landscapes across human cancers reveal a role of palmitoylation in tumorigenesis
Potential small molecules regulating palmitoylation are identified. A Pan-cancer boxplot of BI-2536 IC50 values in normal tissue and stage tumors. B Heatmap of palmitoyl-acyltransferases and de-palmitoyl-acyltransferases gene expression in HCT116 cells treated with BI-2536 (5 μM), etoposide (1 μM), and piperlongumine (10 μM) after 24 h. C Scatter plot of docking energies between BI-2536 and palmitoylation-related proteins. D, E Docking results of ZDHHC4 (D) and ABHD17A (E) proteins with small molecular compound BI-2536