Fig. 4
From: Palmitoylation landscapes across human cancers reveal a role of palmitoylation in tumorigenesis
Myc drives dysregulated palmitoylation. A Clustergram showing the transcription factors that potentially regulate palmitoyl-acyltransferases (Upper) or de-palmitoyl-acyltransferases (Lower), based on the ChEA3 website. B The expression correlation between Myc and palmitoylation-related genes, based on TIMER2.0 website (http://timer.comp-genomics.org/timer/). C Heatmap showing the expression of palmitoyl-acyltransferases or de-palmitoyl-acyltransferases genes in Myc-depleted HCT116 cells. D Myc occupancy on the ZDHHC9 and ABHD17C promoters. ChIP was performed using the endogenous Myc antibody in HCT116 cells. PCR analysis was conducted on the endogenous promoters of ZDHHC9 and ABHD17C genes. E Global palmitoylation levels decrease upon Myc depletion in Myc-depleted HCT116 cells