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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Neurotrophin-3 promotes peripheral nerve regeneration by maintaining a repair state of Schwann cells after chronic denervation via the TrkC/ERK/c-Jun pathway

Fig. 3

NT-3 promotes peripheral nerve regeneration after chronic denervation by maintaining high levels of c-Jun. a Representative images of peripheral nerve regeneration observed using immunofluorescence staining. S100β labeled myelin and NF-labeled axons; scale bar, 100 μm. b Number of regenerated axons per 10,000 µm2 in each group, n = 12 from 4 rats. c Representative images of myelination of regenerated axons in each group observed by TEM; scale bar, 2 μm. d Statistical analysis of myelination in each group, n = 48 or 63 from 3 rats. All numerical data were analyzed using one-way ANOVA with Tukey’s multiple comparison test and are presented as mean ± SEM. **P < 0.005, ****P < 0.0001

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