Fig. 6

Simulated ischemia–reperfusion (IR) in human lung endothelial and epithelial cell cultures induced similar pathways as reported in human lung transplants (11). Dark red nodes indicate upregulated pathway clusters, while blue nodes indicate downregulated clusters observed in human lung transplants. Blue-labeled tags are attached to the pathway boxes if identified in epithelial cells (BEAS-2B) and pink-labeled tags if identified in endothelial cells (HPMEC)