Fig. 4

Simulated ischemia–reperfusion (IR) in lung transplantation induces inflammation and cell type specific gene expression in human lung epithelial cells. Network visualization of significant pathways are shown using EnrichmentMap and AutoAnnotate in Cytoscape software. Human epithelial cells (BEAS-2B) IR model showed upregulation (red nodes) in inflammation, vascular process, and epithelial process themes, and downregulation (blue nodes) in DNA, RNA, protein, and mitochondria themes