Fig. 4

Quantification of immune cell diversity adjacent to the high-EMT tumor programs. a, b, c and d Co-localization of Treg (a), Tex (b), TAM (c), and MDSC (d) cells in stage I samples using the spatial transcriptome data. e Co-localization of the cells of states 4 (up) and 5 (down) for stage I malignant tumor cells at the end of evolutionary trajectory. f, g, h and i Co-localization of Treg (f), Tex (g), TAM (h), and MDSC (i) cells in the stage III samples determined by the spatial transcriptome data. e Co-localization of the cells of clusters 4 (up) and 7 (down) for stage III malignant tumor cells at the end of evolutionary trajectory