Fig. 2

MTB and routine NGS. a Bar plot showing MTB case mix (tumor types), pie chart displaying NGS and other profiling approaches (for abbreviations see the specific section), and flow diagram grouping patients by testing: tDNA, ctDNA and tDNA/ctDNA. For each group, number of patients are displayed without and with actionable alterations, sorted by OncoKB level and color-coded by origin (from tDNA, ctDNA or both: yellow, red and orange, respectively). Dotted blue, green and red boxes identify patients with actionable alterations of any kind, with actionable/unexploited alterations in the MTB setting, and alterations exclusively detected in ctDNA, respectively. b case mix, molecular profiling and flow diagram (tDNA only) from patients undergoing routine NGS. c actionable and actionable/unexploited alterations (top and bottom histograms, respectively), and their OncoKB level distribution among the three MTB groups and routine NGS patients. Group significance is noted