| Univariable analysis | Multivariable analysisa | Multivariable analysisb | ||||
---|---|---|---|---|---|---|---|
Variables | HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | |
Gender | |||||||
 Female | Reference |  |  |  |  |  | |
 Male | 1.10 (0.73 to 1.66) | 0.640 |  |  |  |  | |
Age | |||||||
  < 60 years | Reference |  |  |  |  |  | |
  > 60 years | 1.30 (0.85 to 1.99) | 0.223 |  |  |  |  | |
Gall stone | |||||||
 Absent | Reference |  |  |  |  |  | |
 Present | 1.36 (0.91 to 2.06) | 0.137 |  |  |  |  | |
Tumor size | |||||||
 < 3 cm | Reference |  |  |  |  |  | |
 > 3 cm | 1.15 (0.76 to 1.73) | 0.513 |  |  |  |  | |
TNM stage | |||||||
 Low (I.II. III) | Reference |  | Reference |  | Reference |  | |
 High(IV) | 6.11 (3.84 to 9.72) |  < 0.001 | 4.04 (2.07to7.87) |  < 0.001 | 4.14 (2.12 to 8.09) |  < 0.001 | |
Surgical margin | |||||||
 R0 | 0.16 (0.10 to 0.25) |  < 0.001 | 0.51 (0.28to0.92) | 0.026 | 0.51 (0.28 to 0.92) | 0.025 | |
 R1 | Reference |  | Reference |  | Reference |  | |
Adjuvant therapy | |||||||
 Present | 1.14 (0.74 to 1.73) | 0.555 | 0.58 (0.36to0.92) | 0.021 | 0.59 (0.37 to 0.94) | 0.027 | |
 Absent | Reference |  | Reference |  | Reference |  | |
Histologic differentiation | |||||||
 Moderate. Well | Reference |  | Reference |  | Reference |  | |
 Poor | 7.04 (4.36 to 11.36) |  < 0.001 | 5.06 (3.00to8.55) |  < 0.001 | 5.05 (3.00 to 8.53) |  < 0.001 | |
TIM3 | |||||||
 Low | Reference |  | Reference |  |  |  | |
 High | 1.57 (1.03 to 2.38) | 0.036 | 1.16 (0.70to1.91) | 0.561 |  |  | |
PD1 | |||||||
 Low | Reference |  | Reference |  |  |  | |
 High | 2.15 (1.37 to 3.36) |  < 0.001 | 1.54 (0.91to2.62) | 0.111 |  |  | |
GROUP | |||||||
 GROUPI | Reference |  |  |  | Reference |  | |
 GROUPII | 1.56 (0.88 to 2.77) | 0.13 |  |  | 1.54 (0.86 to 2.76) | 0.142 | |
 GROUPIII | 2.27 (1.36 to 3.77) | 0.002 |  |  | 1.80 (1.08 to 3.02) | 0.025 |