Characteristic | Â | PD1 expression | TIM3 expression | PD1/TIM3 co-high expression | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Cases.n | High | Low | P value | High | Low | P value | Present | Absent | P value | |
Gender | Â | Â | Â | 0.706 | Â | Â | 0.954 | Â | Â | 0.689 |
   Female | 61 | 39 | 22 |  | 32 | 29 |  | 29 | 32 |  |
   Male | 66 | 39 | 27 |  | 36 | 30 |  | 28 | 38 |  |
Age | Â | Â | Â | 0.913 | Â | Â | 0.934 | Â | Â | 0.452 |
    < 60 years | 50 | 31 | 19 |  | 27 | 23 |  | 25 | 25 |  |
    > 60 years | 77 | 47 | 30 |  | 41 | 36 |  | 32 | 45 |  |
Tumor size | Â | Â | Â | 0.813 | Â | Â | 0.824 | Â | Â | 0.878 |
 > 3 cm | 67 | 40 | 27 |  | 37 | 30 |  | 31 | 36 |  |
    < 3 cm | 60 | 38 | 22 |  | 31 | 29 |  | 26 | 34 |  |
Microvascular invasion | Â | Â | Â | 0.835 | Â | Â | 0.955 | Â | Â | 0.953 |
   no | 75 | 45 | 30 |  | 40 | 35 |  | 33 | 42 |  |
   yes | 52 | 33 | 19 |  | 28 | 24 |  | 24 | 28 |  |
T | Â | Â | Â | 0.029 | Â | Â | 0.962 | Â | Â | 0.243 |
   Low(1.2) | 46 | 22 | 24 |  | 24 | 22 |  | 17 | 29 |  |
   High(3.4) | 81 | 56 | 25 |  | 44 | 37 |  | 40 | 41 |  |
N | Â | Â | Â | 0.002 | Â | Â | 0.053 | Â | Â | 0.013 |
   Low(0) | 52 | 23 | 29 |  | 22 | 30 |  | 16 | 36 |  |
   High(1.2) | 75 | 55 | 20 |  | 46 | 29 |  | 41 | 34 |  |
M | Â | Â | Â | 0.030 | Â | Â | 0.893 | Â | Â | 0.274 |
   Absent(0) | 94 | 52 | 42 |  | 50 | 44 |  | 39 | 55 |  |
   Present(1) | 33 | 26 | 7 |  | 18 | 15 |  | 18 | 15 |  |
TNM stage | Â | Â | Â | 0.014 | Â | Â | 0.270 | Â | Â | 0.075 |
   Low(I.II.III) | 59 | 29 | 30 |  | 28 | 31 |  | 21 | 38 |  |
   High(IV) | 68 | 49 | 19 |  | 40 | 28 |  | 36 | 32 |  |
Histologic differentiation | Â | Â | 0.039 | Â | Â | 0.186 | Â | Â | 0.061 | |
   Moderate. Well | 75 | 40 | 35 |  | 36 | 39 |  | 28 | 47 |  |
   Poor | 52 | 38 | 14 |  | 32 | 20 |  | 29 | 23 |  |
CA19-9 | Â | Â | Â | 0.539 | Â | Â | 0.882 | Â | Â | 0.791 |
   Negative | 54 | 31 | 23 |  | 28 | 26 |  | 23 | 31 |  |
   Positive | 73 | 47 | 26 |  | 40 | 33 |  | 34 | 39 |  |
CEA | Â | Â | Â | 0.275 | Â | Â | 0.880 | Â | Â | 0.627 |
   Negative | 82 | 47 | 35 |  | 43 | 39 |  | 35 | 47 |  |
   Positive | 45 | 31 | 14 |  | 25 | 20 |  | 22 | 23 |  |